CD44v6和基质金属蛋白酶-9在喉鳞状细胞癌中的表达及意义
[Expression and significance of CD44v6 and MMP-9 in laryngeal squamous cell carcinoma].
作者信息
Qin Gang, Li Wanrong, Sun Xingwang, Zhu Lin, Chen Zhengnong
机构信息
Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Aug;19(15):688-91.
OBJECTIVE
To investigate the clinical implication and the expression of CD44v6 and MMP-9 protein in laryngeal squamous cell carcinoma (LSCC).
METHOD
Twenty-seven samples of LSCC and eight biopsies of adjacent non-cancerous tissue were detected with immunohistochemical technique (SABC method). The relationship between positive expression of CD44v6 or MMP-9 in LSCC and invasion or metastasis was analyzed.
RESULT
Both CD44v6 and MMP-9 overexpressed in LSCC. The positive expression of CD44v6 was correlated with LSCC pathologic grade, cervical lymph node metastasis and postoperation survival rate (P < 0.05). The expression of MMP-9 was positively correlated with clinical staging and cervical lymph node metastasis (P < 0.05). There was a significant positive correlation between the expression of CD44v6 and MMP-9 (P < 0.01).
CONCLUSION
There is a relationship between the expression of CD44 and MMP-9. CD44v6 and MMP-9 might be served as an objective indicator for lymph nodal metastatic potency, tumor invasion and prognosis in LSCC.
目的
探讨CD44v6和基质金属蛋白酶-9（MMP-9）蛋白在喉鳞状细胞癌（LSCC）中的临床意义及表达情况。
方法
采用免疫组织化学技术（SABC法）检测27例LSCC标本及8例癌旁非癌组织活检标本。分析LSCC中CD44v6或MMP-9阳性表达与侵袭及转移的关系。
结果
CD44v6和MMP-9在LSCC中均呈过表达。CD44v6的阳性表达与LSCC病理分级、颈部淋巴结转移及术后生存率相关（P<0.05）。MMP-9的表达与临床分期及颈部淋巴结转移呈正相关（P<0.05）。CD44v6与MMP-9的表达呈显著正相关（P<0.01）。
结论
CD44与MMP-9的表达之间存在关联。CD44v6和MMP-9可能作为LSCC淋巴结转移潜能、肿瘤侵袭及预后的客观指标。
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