Wang Xiaoqian, Wang Jiqun, Shan Yanchun, Jia Haiying, He Long, Luo Sijin, Zhang Tao
Department of Otorhinolaryngology, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Nov;19(21):964-6.
To investigate the expression and the clinical significance of proto-oncogene cerbB-2 proteins p185 and adhesion molecules CD44v6 in laryngeal squamous cell carcinomas (LSCC) and the relationship between them.
expression of p185 and CD44v6 was studied by immunohistochemical analysis from 63 cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal cord polyp(VCP).
There were no expression of p185in VCP, Significant differences (P < 0.05) were observed between the two group; there was significant differences among the different pathologic degree I, II, III; The expression of p185 was not related to age and clinical stage. Significant differences (P < 0.05) were found among LSCC, VCP and ASM; there was no differences between the different pathologic degree I, II, III. The expression of CD44v6 was not related to age and clinical stage. Significant correlation was observed between the expression of p185 and CD44v6 in LSCC.
p185 probably plays an important role during the carcinogenesis and progression process of LSCC. While CD44v6 has the important function only in the carcinogenesis process of LSCC. The expression of p185 and CD44v6 were higher in ASM than in VCP. It indicates that p185 and CD44v6 were probably the unstable factor in ASM which related to the recurrent of laryngeal carcinoma, and they may cooperate with each other.
探讨原癌基因cerbB - 2蛋白p185及黏附分子CD44v6在喉鳞状细胞癌（LSCC）中的表达及其临床意义，以及它们之间的关系。
采用免疫组化分析法研究63例LSCC、20例癌旁安全切缘组织（ASM）及18例声带息肉（VCP）中p185和CD44v6的表达。
VCP中无p185表达，两组间差异有统计学意义（P < 0.05）；不同病理分级Ⅰ、Ⅱ、Ⅲ级之间差异有统计学意义；p185的表达与年龄及临床分期无关。LSCC、VCP和ASM之间差异有统计学意义（P < 0.05）；不同病理分级Ⅰ、Ⅱ、Ⅲ级之间无差异。CD44v6的表达与年龄及临床分期无关。LSCC中p185与CD44v6的表达呈显著相关。
p185可能在LSCC的发生发展过程中起重要作用。而CD44v6仅在LSCC的发生过程中起重要作用。ASM中p185和CD44v6的表达高于VCP。这表明p185和CD44v6可能是ASM中与喉癌复发相关的不稳定因素，且它们可能相互协作。
