Wang S L, Yang Q, Xiao B K, Jiang Y S, Chen E H
Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Hubei Medical University, Wuhan 430060.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000 Oct;14(10):446-8.
To study the correlation between the expression of CD44s, CD44v6 and the clinicopathological characters of laryngeal squamous cell carcinoma (LSCC) so as to analyze the role of them in occurrence and progression of LSCC.
Expression of CD44 and CD44v6 in 46 cases of LSCC and 20 cases of adjacent normal tissues was inspected with immunohistochemical SP method.
The expression of CD44s increased significantly in lymphnode metastasis group (94.4%) and stage III-IV group (96.2%), but decreased in non-lymphnode metastasis group (67.9%) and stage I-II group (55.0%). The expression of CD44v6 was lower (21.7%), which wasn't associated with any clinicopathological characters.
The role of CD44 and CD44v6 in carcinoma maybe dependent on the species, type of carcinoma, and the expression of CD44s may be a biologic marker to evaluate metastasis of LSCC.
研究CD44s、CD44v6的表达与喉鳞状细胞癌（LSCC）临床病理特征之间的相关性，以分析它们在LSCC发生发展中的作用。
采用免疫组织化学SP法检测46例LSCC及20例癌旁正常组织中CD44及CD44v6的表达。
CD44s在淋巴结转移组（94.4%）和Ⅲ-Ⅳ期组（96.2%）中的表达显著升高，而在无淋巴结转移组（67.9%）和Ⅰ-Ⅱ期组（55.0%）中表达降低。CD44v6的表达较低（21.7%），且与任何临床病理特征均无相关性。
CD44和CD44v6在癌中的作用可能取决于癌的种类、类型，CD44s的表达可能是评估LSCC转移的生物学标志物。
