Pardi Fabio, Levinson Douglas F, Lewis Cathryn M
Department of Medical and Molecular Genetics, King's College London, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom.
Bioinformatics. 2005 Dec 15;21(24):4430-1. doi: 10.1093/bioinformatics/bti725. Epub 2005 Oct 25.
Meta-analysis can be used to pool results of genome-wide linkage scans. This is of great value in complex diseases, where replication of linked regions occurs infrequently. The genome search meta-analysis (GSMA) method is widely used for this analysis, and a computer program is now available to implement the GSMA.
荟萃分析可用于汇总全基因组连锁扫描的结果。这在复杂疾病中具有重要价值,因为连锁区域的重复出现频率较低。基因组搜索荟萃分析(GSMA)方法广泛用于此分析,并且现在有一个计算机程序可用于实施GSMA。