Lebenthal Y, Gat-Yablonski G, Shtaif B, Padoa A, Phillip M, Lazar L
Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tiqva 49202, Israel.
J Clin Endocrinol Metab. 2006 Jan;91(1):328-31. doi: 10.1210/jc.2005-0204. Epub 2005 Oct 25.
Ghrelin levels gradually decrease throughout childhood and with advancing pubertal stage. The change during puberty is more pronounced in boys than girls.
The objective of the study was to investigate whether the pubertal drop in ghrelin secretion is modified by the increase in sex hormones.
Ghrelin levels were measured in 34 short peripubertal children (17 boys and 17 girls) aged 8-12.5 yr before and after sex hormone priming for GH stimulation testing.
In boys, priming with testosterone increased testosterone to pubertal levels (23.7 +/- 7.1 nmol/liter), which in turn induced a marked decrease in ghrelin (from 1615.8 +/- 418.6 to 1390.0 +/- 352.0 pg/ml) and leptin (from 8.0 +/- 4.5 to 5.8 +/- 3.2 ng/ml) and an increase in IGF-I (from 162.7 +/- 52.8 to 291.1 +/- 101.6 ng/ml) (P < 0.001 for all parameters). In girls, priming with estrogen led to a supraphysiological increase in estradiol levels (1313.8 +/- 438.0 pmol/liter), which had no effect on ghrelin, leptin, or IGF-I. There was no correlation between ghrelin levels and levels of sex hormones, leptin, or body mass index in either boys or girls.
A pharmacological increase in sex hormones is associated with a marked decline in circulating levels of ghrelin in boys but not girls. Additional longitudinal studies through puberty are needed to elucidate the physiological interaction between sex hormones and ghrelin.
胃饥饿素水平在整个儿童期会逐渐下降，并随着青春期的推进而降低。青春期的这种变化在男孩中比女孩中更为明显。
本研究的目的是调查性激素增加是否会改变青春期胃饥饿素分泌的下降情况。
对34名8至12.5岁青春期前身材矮小的儿童（17名男孩和17名女孩）在进行生长激素刺激试验的性激素激发前后测量胃饥饿素水平。
在男孩中，用睾酮激发使睾酮水平升至青春期水平（23.7±7.1 nmol/升），这反过来又导致胃饥饿素（从1615.8±418.6降至1390.0±352.0 pg/ml）和瘦素（从8.0±4.5降至5.8±3.2 ng/ml）显著下降，以及胰岛素样生长因子-I升高（从162.7±52.8升至291.1±101.6 ng/ml）（所有参数P<0.001）。在女孩中，用雌激素激发导致雌二醇水平超生理升高（1313.8±438.0 pmol/升），这对胃饥饿素、瘦素或胰岛素样生长因子-I没有影响。男孩或女孩的胃饥饿素水平与性激素水平、瘦素或体重指数之间均无相关性。
性激素的药理学增加与男孩而非女孩循环中胃饥饿素水平的显著下降有关。需要在青春期进行更多的纵向研究以阐明性激素与胃饥饿素之间的生理相互作用。
