Canani Luis H, Capp Clarissa, Ng Daniel P K, Choo Serena G L, Maia Ana Luiza, Nabinger Gustavo B, Santos Kátia, Crispim Daisy, Roisemberg Israel, Krolewski Andrzej S, Gross Jorge L
Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Diabetes. 2005 Nov;54(11):3326-30. doi: 10.2337/diabetes.54.11.3326.
The intestinal fatty-acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] <20 microg/min; n = 529), microalbuminuria (UAE 20-199 microg/min; n = 217), or proteinuria (UAE >199 microg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1-5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0-7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients.
肠脂肪酸结合蛋白2（FABP2）基因编码一种负责长链脂肪酸吸收的蛋白质。为了检测FABP2是否是2型糖尿病患者肾脏疾病的候选基因，对1042名巴西2型糖尿病患者的功能性A54T多态性进行了基因分型。患者被分为正常白蛋白尿（尿白蛋白排泄率[UAE]<20微克/分钟；n = 529）、微量白蛋白尿（UAE 20 - 199微克/分钟；n = 217）或蛋白尿（UAE>199微克/分钟；n = 160）。还纳入了终末期肾病（ESRD）患者（n = 136）。在对2型糖尿病病程、体重指数、高血压、糖化血红蛋白和胆固醇水平进行校正后，与正常白蛋白尿患者相比，肾脏受累患者中TT基因型的患病率更高（优势比[95%可信区间]2.4[1.1 - 5.4]）。考虑到肾脏受累的不同阶段，风险相似。在第二个独立的患者样本（483名居住在马萨诸塞州的2型糖尿病白种人）中，也观察到TT基因型与蛋白尿或ESRD之间存在显著关联（2.7[1.0 - 7.3]；P = 0.048）。因此，这项研究提供了证据表明FABP2使2型糖尿病患者易患肾脏疾病。
