Felson D T
Department of Medicine, Boston City Hospital, MA 02118.
J Clin Epidemiol. 1992 Aug;45(8):885-92. doi: 10.1016/0895-4356(92)90072-u.
With the proliferation of meta-analyses in the medical literature have come conflicting studies. In addition, observance of guidelines for the performance of meta-analyses has been spotty. Bias may explain conflicting studies and differentiate carefully performed meta-analyses from others. Meta-analysts may fail to anticipate biases which threaten their study's validity. The three stages at which bias can be injected into a meta-analysis are finding studies, selection of the identified studies for the meta-analysis and extraction of data from the selected studies. This manuscript reviews specific types of bias which are common at each of these stages.
随着医学文献中荟萃分析的大量涌现，出现了相互矛盾的研究。此外，对荟萃分析实施指南的遵守情况参差不齐。偏倚可能解释相互矛盾的研究，并区分精心进行的荟萃分析与其他分析。荟萃分析者可能未能预见威胁其研究有效性的偏倚。可以在三个阶段将偏倚引入荟萃分析：查找研究、为荟萃分析选择已识别的研究以及从所选研究中提取数据。本文回顾了在这些阶段中每个阶段常见的特定类型的偏倚。
