Nosik N N, Deriabin P G, Isaeva E I, Kondrashina N G, Lavrukhina L A, Inozemtsev A N, Presnova G A, Topoleva T V
Vopr Virusol. 2005 Sep-Oct;50(5):29-32.
The interferon-inducing activity of dry birch bark extract containing betulin and its effect on hepatitis C virus (HCV)-induced infection were studied in the cultured cells. All samples of the extract induced increased interferon (IFN) production when it was orally and intraperitoneally administered. The dose-dependence of the production of IFN showed a direct relation of the extract to interferon induction. There is strong evidence for that the extract can decrease the antigenic and infective activity of HCV in both in vitro experiments and HCV-induced infection in mice. The preventive effect of the extract was found in both the HCV-infected cell cultures and the HCV-infected mice.
研究了含有桦木醇的干桦树皮提取物的干扰素诱导活性及其对丙型肝炎病毒（HCV）诱导感染的影响。在培养细胞中，提取物的所有样品经口服和腹腔注射给药后均诱导干扰素（IFN）产生增加。IFN产生的剂量依赖性表明提取物与干扰素诱导有直接关系。有强有力的证据表明，该提取物在体外实验和小鼠HCV诱导感染中均可降低HCV的抗原性和感染活性。在HCV感染的细胞培养物和HCV感染的小鼠中均发现了该提取物的预防作用。
