Saĭitkulov A M, Ershov F I, Aslanov Kh A, Tazupakhova E B, Maulianov S A, Achilova G Sh, Amanova S Kh
Antibiot Khimioter. 1991 Jul;36(7):39-42.
The interferon-inducing activity of new derivatives of gossypol, a low molecular weight natural polyphenol, and its model compounds was studied in regard to their chemical structure. The active groups required for development of optimal interferon inductors on the basis of the natural polyphenols were defined. As a result of the studies the new interferon inductor AC-1 which is a condensation product of gossypol, a natural polyphenol, and a cellulose derivative was isolated. The interferon-inducing activity of AC-1 was investigated with respect to its dose and the administration route. High interferon-inducing activity of the interferon inductor after its administration by any route in doses of 10 to 100 mg/kg was demonstrated. The serum interferon titers reached 2560 units/ml.
研究了低分子量天然多酚棉酚及其模型化合物的新衍生物的干扰素诱导活性与其化学结构的关系。确定了基于天然多酚开发最佳干扰素诱导剂所需的活性基团。研究结果分离出了新型干扰素诱导剂AC-1，它是天然多酚棉酚与纤维素衍生物的缩合产物。研究了AC-1的干扰素诱导活性与其剂量和给药途径的关系。结果表明，以10至100mg/kg的剂量通过任何途径给药后，该干扰素诱导剂均具有高干扰素诱导活性。血清干扰素效价达到2560单位/毫升。
