TLA-2，一种新型的安布勒A类超广谱β-内酰胺酶。
TLA-2, a novel Ambler class A expanded-spectrum beta-lactamase.
作者信息
Girlich Delphine, Poirel Laurent, Schlüter Andreas, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Université Paris XI, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2005 Nov;49(11):4767-70. doi: 10.1128/AAC.49.11.4767-4770.2005.
Abstract
Beta-lactamase TLA-2 is encoded by a 47-kb plasmid isolated from an unidentified bacterial strain from a wastewater treatment plant. TLA-2 is an Ambler class A beta-lactamase that shares 52% amino acid identity with CGA-1 from Chryseobacterium gleum and 51% with TLA-1 from Escherichia coli. The enzyme hydrolyzes mostly cephalosporins.
摘要
β-内酰胺酶TLA-2由一个47 kb的质粒编码，该质粒从一家污水处理厂的一株未鉴定细菌菌株中分离得到。TLA-2是一种安布勒A类β-内酰胺酶，与来自粘金黄杆菌的CGA-1氨基酸同一性为52%，与来自大肠杆菌的TLA-1氨基酸同一性为51%。该酶主要水解头孢菌素。
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