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A probiotic strain of Bacillus polyfermenticus reduces DMH induced precancerous lesions in F344 male rat.多发酵芽孢杆菌的一种益生菌菌株可减少二甲基肼诱导的F344雄性大鼠癌前病变。
Biol Pharm Bull. 2007 Mar;30(3):569-74. doi: 10.1248/bpb.30.569.
2
Tolerance to challenges miming gastrointestinal transit by spores and vegetative cells of Bacillus clausii.克劳氏芽孢杆菌孢子和营养细胞模拟胃肠道转运对挑战的耐受性。
J Appl Microbiol. 2006 Dec;101(6):1208-15. doi: 10.1111/j.1365-2672.2006.03042.x.
3
Dietary supplementation of probiotic Bacillus polyfermenticus, Bispan strain, modulates natural killer cell and T cell subset populations and immunoglobulin G levels in human subjects.膳食补充益生菌多发酵芽孢杆菌Bispan菌株可调节人体自然杀伤细胞、T细胞亚群数量及免疫球蛋白G水平。
J Med Food. 2006 Fall;9(3):321-7. doi: 10.1089/jmf.2006.9.321.
4
Screening for bacillus isolates in the broiler gastrointestinal tract.筛选肉鸡胃肠道中的芽孢杆菌分离株。
Appl Environ Microbiol. 2005 Feb;71(2):968-78. doi: 10.1128/AEM.71.2.968-978.2005.
5
Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species.工业细菌地衣芽孢杆菌的全基因组序列及其与近缘芽孢杆菌物种的比较。
Genome Biol. 2004;5(10):R77. doi: 10.1186/gb-2004-5-10-r77. Epub 2004 Sep 13.
6
Bacillus clausii probiotic strains: antimicrobial and immunomodulatory activities.克劳氏芽孢杆菌益生菌株：抗菌及免疫调节活性
J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S86-90. doi: 10.1097/01.mcg.0000128925.06662.69.
7
Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa.铜绿假单胞菌天然存在的苯唑西林酶OXA-50的生化特性
Antimicrob Agents Chemother. 2004 Jun;48(6):2043-8. doi: 10.1128/AAC.48.6.2043-2048.2004.
8
Characterization of Bacillus probiotics available for human use.可供人类使用的芽孢杆菌益生菌的特性分析。
Appl Environ Microbiol. 2004 Apr;70(4):2161-71. doi: 10.1128/AEM.70.4.2161-2171.2004.
9
The ybxI gene of Bacillus subtilis 168 encodes a class D beta-lactamase of low activity.枯草芽孢杆菌168的ybxI基因编码一种低活性的D类β-内酰胺酶。
Antimicrob Agents Chemother. 2004 Feb;48(2):484-90. doi: 10.1128/AAC.48.2.484-490.2004.
10
Characterization of a new erm-related macrolide resistance gene present in probiotic strains of Bacillus clausii.克劳氏芽孢杆菌益生菌株中存在的一种新的erm相关大环内酯抗性基因的特性分析。
Appl Environ Microbiol. 2004 Jan;70(1):280-4. doi: 10.1128/AEM.70.1.280-284.2004.

克劳氏芽孢杆菌染色体编码的A类β-内酰胺酶BCL-1的分子和生化特性

Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii.

作者信息

Girlich Delphine, Leclercq Roland, Naas Thierry, Nordmann Patrice

机构信息

Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 K. Bicêtre Cedex, France.

出版信息

Antimicrob Agents Chemother. 2007 Nov;51(11):4009-14. doi: 10.1128/AAC.00537-07. Epub 2007 Sep 10.

DOI:10.1128/AAC.00537-07
PMID:17846134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2151419/
Abstract

A chromosomal beta-lactamase gene from Bacillus clausii NR, which is used as a probiotic, was cloned and expressed in Escherichia coli. It encodes a clavulanic acid-susceptible Ambler class A beta-lactamase, BCL-1, with a pI of 5.5 and a molecular mass of ca. 32 kDa. It shares 91% and 62% amino acid identity with the chromosomally encoded PenP penicillinases from B. clausii KSM-K16 and Bacillus licheniformis, respectively. The hydrolytic profile of this beta-lactamase includes penicillins, narrow-spectrum cephalosporins, and cefpirome. This chromosome-encoded enzyme was inducible in B. clausii, and its gene is likely related to upstream-located regulatory genes that share significant identity with those reported to be upstream of the penicillinase gene of B. licheniformis. The bla(BCL-1) gene was located next to the known chromosomal aadD2 gene and the erm34 gene, which encode resistance to aminoglycosides and macrolides, respectively. Similar genes were found in a collection of B. clausii reference strains.

摘要

来自用作益生菌的克劳氏芽孢杆菌NR的一个染色体β-内酰胺酶基因被克隆并在大肠杆菌中表达。它编码一种对克拉维酸敏感的安布勒A类β-内酰胺酶BCL-1，其等电点为5.5，分子量约为32 kDa。它与克劳氏芽孢杆菌KSM-K16和地衣芽孢杆菌染色体编码的PenP青霉素酶分别具有91%和62%的氨基酸同一性。这种β-内酰胺酶的水解谱包括青霉素、窄谱头孢菌素和头孢匹罗。这种染色体编码的酶在克劳氏芽孢杆菌中是可诱导的，其基因可能与上游的调控基因相关，这些调控基因与报道的地衣芽孢杆菌青霉素酶基因上游的调控基因具有显著同一性。bla(BCL-1)基因位于已知的染色体aadD2基因和erm34基因旁边，这两个基因分别编码对氨基糖苷类和大环内酯类的抗性。在一组克劳氏芽孢杆菌参考菌株中发现了类似的基因。