淀粉样前体蛋白：结构与生物学功能的整合
The amyloid-beta precursor protein: integrating structure with biological function.
作者信息
Reinhard Constanze, Hébert Sébastien S, De Strooper Bart
机构信息
Laboratory for Neuronal Cell Biology and Gene Transfer, Department of Human Genetics, Center for Human Genetics, KU Leuven and VIB, Leuven, Belgium.
出版信息
EMBO J. 2005 Dec 7;24(23):3996-4006. doi: 10.1038/sj.emboj.7600860. Epub 2005 Oct 27.
Abstract
Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.
摘要
淀粉样前体蛋白（APP）的蛋白水解加工产生了阿尔茨海默病的β淀粉样肽。然而，APP本身的生物学功能仍不清楚。在当前的综述中，我们详细研究了APP的不同亚结构域，并试图赋予该蛋白中鉴定出的特定结构以功能意义。
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