Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Rare disease center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Alzheimers Dement. 2024 Jun;20(6):4366-4372. doi: 10.1002/alz.13841. Epub 2024 May 7.
Platelets serve as the primary peripheral reservoir of amyloid beta (Aβ). However, there is limited research on platelet markers in routine blood examinations, particularly with regard to the large platelet ratio (P-LCR) in Alzheimer's disease (AD).
This study included 512 AD patients and 205 healthy controls (HCs). Platelet markers and apolipoprotein E (APOE) 4 status were assessed in all participants.
The study revealed that P-LCR was significantly elevated in AD patients compared to HCs. In AD patients carrying APOE4, P-LCR significantly negatively correlated with Montreal Cognitive Assessment scores. There was an observed increasing trend in the rate of change in P-LCR with disease progression. Binary logistic regression analysis indicated that P-LCR may constitute a risk factor for AD, after adjusting for age, sex, APOE4, and body mass index.
P-LCR is associated with disease severity in AD patients carrying APOE4. P-LCR may be a promising marker to reflect platelet activity in AD patients.
P-LCR significantly negatively correlated with MoCA scores in AD patients with APOE4. The rate of change in P-LCR showed an increasing trend with disease progression. P-LCR may be a risk factor for AD.
血小板是淀粉样β（Aβ）的主要外周储存库。然而，在常规血液检查中，血小板标志物的研究有限，特别是在阿尔茨海默病（AD）中，大血小板比（P-LCR）的研究较少。
本研究纳入了 512 例 AD 患者和 205 例健康对照者（HCs）。所有参与者均评估了血小板标志物和载脂蛋白 E（APOE）4 状态。
研究显示，AD 患者的 P-LCR 明显高于 HCs。在携带 APOE4 的 AD 患者中，P-LCR 与蒙特利尔认知评估评分呈显著负相关。随着疾病进展，P-LCR 的变化率呈上升趋势。经年龄、性别、APOE4 和体重指数调整后，二元逻辑回归分析表明 P-LCR 可能是 AD 的危险因素。
P-LCR 与携带 APOE4 的 AD 患者的疾病严重程度相关。P-LCR 可能是反映 AD 患者血小板活性的有前途的标志物。
携带 APOE4 的 AD 患者中，P-LCR 与 MoCA 评分显著负相关。P-LCR 的变化率随着疾病的进展呈上升趋势。P-LCR 可能是 AD 的危险因素。
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