土耳其东部凡城地区的慢性丁型肝炎病毒感染

Chronic hepatitis delta virus infection in Van region of eastern Turkey.

作者信息

Türkdoğan M Kürşad, Bozkurt Hamza, Uygan Ismail, Tuncer Ilyas, Irmak Hasan, Buzgan Turan, Akdeniz Hayrettin

机构信息

Department of Gastroenterology, School of Medicine, Yüzüncü Yil University, 65200 Van, Ankara, Turkey.

出版信息

Turk J Gastroenterol. 2005 Mar;16(1):17-20.

PMID:16252183

Abstract

BACKGROUND/AIMS: Hepatitis delta virus infection is an important cause of liver morbidity and mortality worldwide. In Eastern Turkey, hepatitis B virus infection is the major cause of chronic liver diseases. We aimed to research the role of hepatitis delta virus infection in chronic liver diseases related to hepatitis B virus infection in the Van region of Eastern Turkey.

METHODS

Serological markers of hepatitis B virus and hepatitis delta virus infection [HBsAg, HbeAg, Anti-HBe and Anti- hepatitis delta virus total (IgM+IgG)] were determined by ELISA test in patients with chronic hepatitis and cirrhosis. Serum hepatitis B virus DNA was determined by polymerase chain reaction (PCR) method in chronic hepatitis B patients.

RESULTS

Hepatitis delta virus infection was detected in 5% (7/138) of asymptomatic hepatitis B virus carriers, in 16% (24/148) of chronic hepatitis B patients and in 45% (34/75) of cirrhotic hepatitis B virus patients. hepatitis delta virus infection showed a three-fold increase in chronic hepatitis (p<0.01) and nine-fold increase in cirrhosis (p<0.001) compared to hepatitis delta virus carriers. Also, it was three times more frequent in cirrhosis (p<0.001) compared to chronic hepatitis. Chronic hepatitis delta virus infection was equally distributed between sexes in patients with chronic hepatitis B virus infection, whereas chronic hepatitis B virus infection alone was three times more frequent in males (p<0.001). Mean ages of hepatitis delta virus carriers, chronic hepatitis D and hepatitis delta virus cirrhosis patients were 30.7+/-8 (14-65), 36+/-13 (19-70) and 44 +/-16 (25-55), respectively.

CONCLUSIONS

The higher prevalence of hepatitis delta virus infection in more severe form of hepatitis B virus infection suggests that hepatitis delta virus infection increases the severity of chronic hepatitis B virus infection in the Van region. hepatitis delta virus infection remains a second major cause of chronic liver diseases in Eastern Turkey in spite of its decreasing prevalence in Western countries and in Western Turkey.

摘要

背景/目的：丁型肝炎病毒感染是全球肝脏发病和死亡的重要原因。在土耳其东部，乙型肝炎病毒感染是慢性肝病的主要原因。我们旨在研究丁型肝炎病毒感染在土耳其东部凡城地区与乙型肝炎病毒感染相关的慢性肝病中的作用。

方法

采用酶联免疫吸附试验（ELISA）检测慢性肝炎和肝硬化患者乙型肝炎病毒和丁型肝炎病毒感染的血清学标志物[乙肝表面抗原（HBsAg）、乙肝e抗原（HbeAg）、乙肝e抗体（Anti-HBe）和抗丁型肝炎病毒总量（IgM+IgG）]。采用聚合酶链反应（PCR）法检测慢性乙型肝炎患者血清中的乙肝病毒DNA。

结果

无症状乙肝病毒携带者中丁型肝炎病毒感染率为5%（7/138），慢性乙型肝炎患者中为16%（24/148），乙型肝炎肝硬化患者中为45%（34/75）。与丁型肝炎病毒携带者相比，慢性乙型肝炎患者中丁型肝炎病毒感染增加了两倍（p<0.01），肝硬化患者中增加了九倍（p<0.001）。此外，与慢性乙型肝炎相比，肝硬化患者中丁型肝炎病毒感染的频率高出三倍（p<0.001）。在慢性乙型肝炎病毒感染患者中，慢性丁型肝炎病毒感染在男女中分布均匀，而单纯慢性乙型肝炎病毒感染在男性中的频率高出三倍（p<0.001）。丁型肝炎病毒携带者、慢性丁型肝炎患者和丁型肝炎肝硬化患者的平均年龄分别为30.7±8岁（14-65岁）、36±13岁（19-70岁）和44±16岁（25-55岁）。