长期和短期戒毒的甲基苯丙胺使用者右侧前扣带回皮质脑血流量减少。
Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users.
作者信息
Hwang Jaeuk, Lyoo In Kyoon, Kim Seog Ju, Sung Young Hoon, Bae Soojeong, Cho Sung-Nam, Lee Ho Young, Lee Dong Soo, Renshaw Perry F
机构信息
Department of Psychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.
出版信息
Drug Alcohol Depend. 2006 Apr 28;82(2):177-81. doi: 10.1016/j.drugalcdep.2005.09.011. Epub 2005 Oct 25.
BACKGROUND
The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users.
METHODS
Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl-propylene amine oxime ((99m)Tc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (>or=6 months) abstinence.
RESULTS
MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users.
CONCLUSIONS
We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.
背景
本研究的目的是探讨短期和长期戒断甲基苯丙胺（MA）使用者的相对局部脑血流量（rCBF）变化。
方法
通过99m锝-六甲基丙烯胺肟（（99m）Tc-HMPAO）单光子发射计算机断层扫描（SPECT）比较40名戒断MA使用者和23名健康对照者的相对rCBF。还对短期（<6个月）和长期（≥6个月）戒断的MA使用者组中发现有显著差异区域的相对rCBF进行了比较。
结果
与健康对照者相比，MA使用者右侧前扣带回皮质（布罗德曼区32）的相对rCBF降低。长期戒断的MA使用者的rCBF显著高于短期戒断的MA使用者。
结论
我们报告，戒断MA使用者的前扣带回皮质rCBF降低，长期戒断者的相对降低幅度较小。
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