Wu Albert W, Huang I-Chan, Gifford Allen L, Spritzer Karen L, Bozzette Samuel A, Hays Ron D
Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205-1901, USA.
HIV Clin Trials. 2005 May-Jun;6(3):147-57. doi: 10.1310/BPNB-XELF-AXFQ-QQTL.
Optimizing health-related quality of life (HRQOL) is an increasingly important goal in the treatment of HIV/AIDS. Interpretation of HRQOL scores in clinical trials is enhanced by comparative data.
To estimate AIDS Clinical Trials Group (ACTG) QOL 601-602 questionnaire scale scores for a nationally representative sample of persons in care for HIV.
The study cohort was from the HIV Cost and Services Utilization Study (HCSUS), a multistage national probability sample. We derived HCSUS HRQOL scale scores from the items shared between the ACTG QOL 601-602 and HCSUS HRQOL questionnaires using regression equations. Cronbach's alpha coefficient was used to estimate the reliability of the multi-item scales in the ACTG QOL 601-602 and HCSUS HRQOL instruments. Correlation Coefficients and R2s of regression models were calculated to determine the concordance of the models. Multiple regression was used to determine if patient characteristics accounted for differences (residuals) between scores observed from the full HCSUS HRQOL instruments and scores predicted using the subset of shared items in ACTG QOL 601-2.
Internal consistency reliability estimates were acceptable (>0.70) for all scales in the ACTG QOL 601-602 and HCSUS HRQOL instruments. Correlations between corresponding ACTG QOL 601-602 and HCSUS HRQOL scale scores were high (>0.9). The R2s for predicting HCSUS HRQOL scores from the ACTG QOL 601-602 scales were also high (>0.8). For physical functioning, emotional well-being, and general health perceptions, the predictors of differences (residuals) in observed and predicted HCSUS HRQOL scores were gender and CDC stage of HIV infection (P < .05).
This study provides normative data from the US HIV/AIDS population for comparison to the ACTG QOL 601-602 questionnaire. Accuracy of estimation is enhanced if done separately by gender and HIV disease stage.
优化与健康相关的生活质量（HRQOL）是治疗HIV/AIDS日益重要的目标。通过比较数据可增强对临床试验中HRQOL评分的解读。
估计艾滋病临床试验组（ACTG）QOL 601 - 602问卷量表在全国具有代表性的HIV感染者样本中的得分。
研究队列来自HIV成本与服务利用研究（HCSUS），这是一个多阶段全国概率样本。我们使用回归方程从ACTG QOL 601 - 602和HCSUS HRQOL问卷共有的项目中得出HCSUS HRQOL量表得分。Cronbach's alpha系数用于估计ACTG QOL 601 - 602和HCSUS HRQOL工具中多项目量表的信度。计算回归模型的相关系数和R2以确定模型的一致性。使用多元回归来确定患者特征是否解释了从完整的HCSUS HRQOL工具观察到的得分与使用ACTG QOL 601 - 2中共享项目子集预测的得分之间的差异（残差）。
ACTG QOL 601 - 602和HCSUS HRQOL工具中所有量表的内部一致性信度估计值均可接受（>0.70）。相应的ACTG QOL 601 - 602和HCSUS HRQOL量表得分之间的相关性很高（>0.9）。从ACTG QOL 601 - 602量表预测HCSUS HRQOL得分的R2也很高（>0.8）。对于身体功能、情绪健康和总体健康感知，观察到的和预测的HCSUS HRQOL得分差异（残差）的预测因素是性别和HIV感染的CDC阶段（P <.05）。
本研究提供了来自美国HIV/AIDS人群的规范数据，用于与ACTG QOL 601 - 602问卷进行比较。如果按性别和HIV疾病阶段分别进行估计，估计的准确性会提高。
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