Hasan Z A, Hasan M M, al-Hader A A, Takrouri M S
Department of Physiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid.
Middle East J Anaesthesiol. 1992 Feb;11(4):359-67.
The protective effects of subanesthetic and anesthetic doses of propofol and thiopentone against pentylenetetrazol (PTZ)- induced seizures were studied in the rat. Intraperitoneal administration of propofol and thiopentone at doses producing comparable levels of sedation prior to intravenous infusion of PTZ, resulted in a marker and significant increase in PTZ seizure threshold. However, at all doses, the effects of propofol on PTZ convulsive threshold were more profound. These data suggest that propofol is an effective anticonvulsant and affords a greater degree of protection than thiopentone against PTZ-induced seizures in the rat.
在大鼠中研究了亚麻醉剂量和麻醉剂量的丙泊酚与硫喷妥钠对戊四氮（PTZ）诱导惊厥的保护作用。在静脉注射PTZ之前，腹腔注射能产生相当程度镇静作用的丙泊酚和硫喷妥钠剂量，导致PTZ惊厥阈值显著升高。然而，在所有剂量下，丙泊酚对PTZ惊厥阈值的影响更为显著。这些数据表明，丙泊酚是一种有效的抗惊厥药，在大鼠中，其对PTZ诱导惊厥的保护程度比硫喷妥钠更高。
