Hasan Z
Department of Physiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Acta Anaesthesiol Belg. 1997;48(4):239-44.
Pentylenetetrazol (PTZ) seizure threshold was determined in the rat during recovery from anesthesia induced by intravenous administration of propofol (20 mg/kg) or thiopentone (30 mg/kg). Seizure threshold values determined 10 min after the induction of anesthesia by either agents were significantly higher than those determined in control animals, indicating an anticonvulsant effect. With propofol, the initial rise in PTZ convulsive threshold declined rapidly during recovery from anesthesia and returned to control levels 40 min after drug administration. With thiopentone, the initial rise in convulsive threshold also declined during recovery phase but did not return to control levels at 90 min after drug administration. At no time during or after recovery from anesthesia induced by either anesthetic agents, did the PTZ conclusive threshold fall below control values. Thus, using the PTZ convulsive threshold, no proconvulsant effects were detected during the early phase of recovery from propofol or thiopentone induced anesthesia.
在大鼠从静脉注射丙泊酚（20mg/kg）或硫喷妥钠（30mg/kg）诱导的麻醉中恢复期间，测定戊四氮（PTZ）惊厥阈值。在使用任何一种药物诱导麻醉10分钟后测定的惊厥阈值均显著高于在对照动物中测定的值，表明具有抗惊厥作用。使用丙泊酚时，PTZ惊厥阈值的初始升高在从麻醉中恢复期间迅速下降，并在给药后40分钟恢复到对照水平。使用硫喷妥钠时，惊厥阈值的初始升高在恢复阶段也下降，但在给药后90分钟未恢复到对照水平。在从任何一种麻醉剂诱导的麻醉中恢复期间或之后的任何时候，PTZ惊厥阈值均未降至对照值以下。因此，使用PTZ惊厥阈值，在从丙泊酚或硫喷妥钠诱导的麻醉中恢复的早期阶段未检测到促惊厥作用。
