丙泊酚和硫喷妥钠对家兔印防己毒素惊厥阈值的影响。

Effects of propofol and thiopentone on picrotoxin convulsive threshold in the rabbit.

作者信息

Hasan Z, Khatib S, Abu-Laban A

机构信息

Department of Physiology, School of Medicine, Jordan University of Science and Technology, Irbid.

出版信息

Can J Physiol Pharmacol. 1995 Jun;73(6):714-7. doi: 10.1139/y95-092.

DOI:10.1139/y95-092

PMID:7585342

Abstract

The purpose of the present study was to examine the effect of intravenous administration of propofol and thiopentone on picrotoxin-induced seizures using the picrotoxin convulsive threshold test in the rabbit. Neither propofol nor thiopentone at a dose of 1.25 mg/kg had any significant effect on picrotoxin seizure threshold. However, at higher doses (2.5, 5, 10 mg/kg) both propofol and thiopentone produced a significant and dose-dependent increase in the picrotoxin convulsive threshold. These findings suggest that propofol is an effective anticonvulsant against picrotoxin-induced seizures in the rabbit.

摘要

本研究的目的是通过家兔苦味毒惊厥阈值试验，研究静脉注射丙泊酚和硫喷妥钠对苦味毒诱导惊厥的影响。剂量为1.25mg/kg的丙泊酚和硫喷妥钠对苦味毒惊厥阈值均无显著影响。然而，在较高剂量（2.5、5、10mg/kg）时，丙泊酚和硫喷妥钠均使苦味毒惊厥阈值显著升高，且呈剂量依赖性。这些结果表明，丙泊酚是一种有效的抗苦味毒诱导家兔惊厥的抗惊厥药。