新型基于共有序列的禽流感DNA疫苗的免疫原性
Immunogenicity of novel consensus-based DNA vaccines against avian influenza.
作者信息
Laddy Dominick J, Yan Jian, Corbitt Natasha, Kobinger Gary P, Weiner David B
机构信息
Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, University of Manitoba, Winnipeg, Canada.
出版信息
Vaccine. 2007 Apr 20;25(16):2984-2989. doi: 10.1016/j.vaccine.2007.01.063. Epub 2007 Jan 30.
Abstract
The frequency of H5N1 avian influenza outbreaks in China and Eastern Europe has raised concern in the world health community regarding the potential for an influenza pandemic. Efforts to monitor the disease will only provide minimal warning in a global society, and steps must be taken to prevent the morbidity and mortality associated with past pandemics. The current stockpiling of antibody-inducing "bird flu" vaccines assumes the strain that emerges will be the same as strains currently circulating. We propose a novel consensus-based approach to vaccine development, employing a DNA vaccine strategy that can provide more highly cross-reactive cellular immunity against lethal influenza infection. We show such constructs can induce strong cellular immunity against H5 influenza antigens.
摘要
中国和东欧H5N1禽流感疫情的频发引发了世界卫生界对流感大流行可能性的担忧。在全球社会中，监测该疾病的努力只能提供最低限度的预警，因此必须采取措施预防与过去大流行相关的发病和死亡情况。目前储备的可诱导抗体的“禽流感”疫苗假定出现的毒株将与当前流行的毒株相同。我们提出了一种基于共识的新型疫苗研发方法，采用DNA疫苗策略，该策略可以针对致命性流感感染提供更高交叉反应性的细胞免疫。我们证明这种构建体能够诱导针对H5流感抗原的强大细胞免疫。
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