Timofeeva O A
Laboratory of Biologically Active Substances, Ministry of Health, Moscow, U.S.S.R.
Neurosci Lett. 1992 Feb 3;135(2):163-6. doi: 10.1016/0304-3940(92)90427-9.
The evolution of seizures and postseizure inhibitions in the course of 'rapid kindling' and after the termination of stimulation were studied in rabbits with chronically implanted electrodes (neocortex, dorsal hippocampus, amygdala, caudate nucleus). The amygdala (n = 4) or hippocampus (n = 7) was electrically stimulated every 5 min. Generalized convulsions and wide-spread electrographic epileptic changes together with a striking shortening of postictal refractory periods were produced by this procedure within 2-6 h. In most cases, these epileptogenic effects continued their progression after the termination of stimulation for more than 2-4 weeks. The degree of reduction of postseizure inhibition durations was significantly greater than the degree of increase of generalized motor seizure durations. These may be mediated by mechanisms which facilitate the onset of seizure but do not significantly influence seizure expression.
在植入慢性电极（新皮层、背侧海马体、杏仁核、尾状核）的家兔中，研究了“快速点燃”过程中癫痫发作及发作后抑制的演变情况以及刺激终止后的情况。每隔5分钟对杏仁核（n = 4）或海马体（n = 7）进行电刺激。通过该程序在2 - 6小时内产生了全身性惊厥和广泛的脑电图癫痫变化，同时发作后不应期显著缩短。在大多数情况下，这些致痫作用在刺激终止后持续进展超过2 - 4周。发作后抑制持续时间的缩短程度显著大于全身性运动性癫痫发作持续时间的增加程度。这些可能由促进癫痫发作起始但对癫痫发作表现无显著影响的机制介导。
