Malamitsi-Puchner Ariadne, Boutsikou Theodora, Economou Emmanuel, Sarandakou Angeliki, Makrakis Evangelos, Hassiakos Dimitrios, Creatsas George
2nd Department of Obstetrics and Gynecology, University of Athens, Greece.
Mediators Inflamm. 2005 Oct 24;2005(5):293-7. doi: 10.1155/MI.2005.293.
The angiogenic factors vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) are respectively up- and downregulated by hypoxia. We aimed to study circulating levels of the above factors in intrauterine growth restriction (IUGR) and to correlate their levels with the customized centiles of the infants. The study included 25 IUGR and 25 appropriate for gestational age (AGA) full-term, singleton infants and their mothers. Maternal (MS), fetal (UC), and neonatal day 1 (N1) and 4 (N4) blood was examined. MS and N1 PlGF, as well as UC VEGF levels correlated with the customized centiles of the infants (r= 0.39, P=.007, r=0.34, P=.01, and r= -0.41, P=.004, resp). Furthermore, UC, N1, and N4 VEGF levels were higher in girls (r=0.36, P=.01, r=0.33, P=.02, and r=0.41, P=.005 resp). In conclusion, positive and negative correlations of examined factors with the customized centiles of the infant could rely on placental function and intrauterine oxygen concentrations-both being usually lower in IUGR cases-while higher VEGF levels in girls should possibly be attributed to the stimulating action of estrogens.
血管生成因子血管内皮生长因子（VEGF）和胎盘生长因子（PlGF）分别在缺氧状态下上调和下调。我们旨在研究上述因子在宫内生长受限（IUGR）中的循环水平，并将其水平与婴儿的定制百分位数相关联。该研究纳入了25例IUGR和25例足月、单胎且适于胎龄（AGA）的婴儿及其母亲。检测了母亲（MS）、胎儿（脐血，UC）以及新生儿出生第1天（N1）和第4天（N4）的血液。母亲和N1的PlGF以及脐血VEGF水平与婴儿的定制百分位数相关（相关系数分别为r = 0.39，P = 0.007；r = 0.34，P = 0.01；r = -0.41，P = 0.004）。此外，女孩的脐血、N1和N4的VEGF水平较高（相关系数分别为r = 0.36，P = 0.01；r = 0.33，P = 0.02；r = 0.41，P = 0.005）。总之，所检测因子与婴儿定制百分位数之间的正相关和负相关可能依赖于胎盘功能和宫内氧浓度（在IUGR病例中这两者通常较低），而女孩较高的VEGF水平可能应归因于雌激素的刺激作用。
