Arq Neuropsiquiatr. 2005 Sep;63(3B):892-5. doi: 10.1590/s0004-282x2005000500036. Epub 2005 Oct 18.
The treatment of patients with multiple sclerosis (MS) with immunomodulatory drugs, and more recently, with immunosuppressive drugs, have modified the natural history of the disease in the last years. The conclusions and recommendations elaborated by several authors based upon multicenter studies make us review and update concepts, proposing modifications to government institutions in order to improve the assistance to MS patients, the main purpose of this work. Herein, the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology judged important to update the recommendations concerning MS diagnosis criteria, classification of progression patterns, foundation of reference centers and the use of immunomodulatory drugs.
在过去几年中，使用免疫调节药物以及最近使用免疫抑制药物治疗多发性硬化症（MS）患者，已经改变了该疾病的自然病程。几位作者基于多中心研究得出的结论和建议促使我们重新审视和更新相关概念，向政府机构提出修改建议，以改善对MS患者的援助，这是本研究的主要目的。在此，巴西神经病学学会神经免疫学科学部认为更新关于MS诊断标准、疾病进展模式分类、参考中心设立以及免疫调节药物使用的建议很重要。
