Comini-Frota Elizabeth Regina, Vasconcelos Cláudia C F, Mendes Maria Fernanda
Universidade José do Rosário Vellano, UNIFENAS, Belo Horizonte MG, Brasil.
Academia Brasileira de Neurologia, Departamento Científico de Neuroimunologia (DCNI), São Paulo SP, Brasil.
Arq Neuropsiquiatr. 2017 Jan;75(1):57-65. doi: 10.1590/0004-282X20160185.
Multiple sclerosis has become an ever-increasing challenge to neurologists. With the release of the latest medications on the market, Brazilian neurologists feel divided between following their patients' evolution in accordance with the strict rules established by the Brazilian Ministry of Health regarding drug distribution, or following disease progression and worsening in accordance with the evidence in the literature. Therefore, a systematic review of the main published treatment guidelines was conducted and an escalating therapy proposed for guiding multiple sclerosis patient treatment in Brazil.
多发性硬化症已成为神经科医生日益严峻的挑战。随着市场上最新药物的推出，巴西神经科医生在按照巴西卫生部制定的严格药物分发规定跟踪患者病情进展，还是依据文献中的证据跟踪疾病进展和恶化情况之间感到左右为难。因此，对主要已发表的治疗指南进行了系统回顾，并提出了一种逐步升级的疗法，以指导巴西多发性硬化症患者的治疗。
