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听神经瘤的保守治疗

Conservative management of acoustic neuromas.

作者信息

Nedzelski J M, Schessel D A, Pfleiderer A, Kassel E E, Rowed D W

机构信息

Department of Otolaryngology, Sunnybrook Health Science Center, Toronto, Ontario, Canada.

出版信息

Otolaryngol Clin North Am. 1992 Jun;25(3):691-705.

PMID:1625870
Abstract

The results of this study and others document the biologic behavior of acoustic neuromas. In view of the evidence presented, which describes both variable rates of individual tumor growth and spontaneous regression in size, it would seem prudent that before selecting a nonsurgical treatment modality, the growth rate for the particular tumor in question should be established. To date, none of the literature that addresses the use of focused irradiation has attempted to do so. Our study as well as those of others suggests that the growth rate of acoustic neuromas becomes predictable over time. Based on this observation, a conservative (nontumor excision) management strategy is proposed for selected individuals. Patients to whom this management philosophy has been recommended or who themselves have chosen this option are seen twice yearly. Each visit consists of a thorough neurotologic examination as well as high-definition CT or MRI. Careful comparison of the clinical course as well as calculation of the tumor size is carried out in each instance. If the clinical course and rate of tumor growth remain unchanged over a 3-year follow-up, annual assessments are recommended. In the event of tumor enlargement, surgery may or may not be recommended, depending on the rate of growth and the age of the patient. Our experience suggests that a rate of growth equal to or exceeding 0.2 cm per year constitutes an indication for tumor removal.

摘要

本研究及其他研究结果记录了听神经瘤的生物学行为。鉴于所呈现的证据描述了个体肿瘤生长速度的差异以及大小的自发缩小,在选择非手术治疗方式之前,确定所讨论的特定肿瘤的生长速度似乎是明智的。迄今为止,涉及聚焦照射应用的文献均未尝试这样做。我们的研究以及其他研究表明,听神经瘤的生长速度随时间推移变得可预测。基于这一观察结果,为部分患者提出了一种保守(非肿瘤切除)的管理策略。被推荐采用这种管理理念或自行选择该方案的患者每年接受两次检查。每次检查包括全面的神经耳科学检查以及高清CT或MRI。每次都要仔细比较临床病程并计算肿瘤大小。如果在3年随访期间临床病程和肿瘤生长速度保持不变,建议每年进行评估。如果肿瘤增大,根据生长速度和患者年龄,可能建议或不建议进行手术。我们的经验表明,每年生长速度等于或超过0.2厘米表明需要切除肿瘤。

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