Al Sanosi Abdulrahman, Fagan Paul A, Biggs Nigel D W
Department of Otolaryngology, King Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia.
Skull Base. 2006 May;16(2):95-100. doi: 10.1055/s-2006-934112.
To identify those patients with vestibular schwannoma (acoustic neuroma) in whom treatment becomes necessary.
Retrospective chart review.
A total of 205 patients with small tumors were followed for a mean of 40.8 months. The longest follow-up was 180 months. One hundred and ninety-seven patients had a follow-up of more than 12 months. Eight patients with a follow-up of less than 12 months were excluded from the study. In 136 patients (66.3%) the tumor did not grow. Forty-seven patients (23.9%) showed some evidence of slow growth. Eight of 197 patients (4%) had rapid growth and 6 patients (3%) had radiological evidence of tumor regression. Fifteen patients came to surgery. Five of these showed rapid growth, four developed ataxia in whom tumor growth was slow, three had ataxia without tumor growth, two patients developed brainstem compression, and one patient elected to proceed to surgery, although there were no tumor growth or symptoms.
Few patients with small tumors will come to surgery in the short term. Perhaps the majority of patients with such small tumors will not need surgery. Long-term follow-up studies of 20 years or more are required to be come more confident about the natural history of these tumors. This study continues.
确定那些有必要接受治疗的前庭神经鞘瘤(听神经瘤)患者。
回顾性病历审查。
共对205例小肿瘤患者进行了平均40.8个月的随访。最长随访时间为180个月。197例患者的随访时间超过12个月。8例随访时间不足12个月的患者被排除在研究之外。136例患者(66.3%)的肿瘤未生长。47例患者(23.9%)有缓慢生长的迹象。197例患者中有8例(4%)肿瘤快速生长,6例患者(3%)有肿瘤消退的影像学证据。15例患者接受了手术。其中5例显示肿瘤快速生长,4例出现共济失调但肿瘤生长缓慢,3例有共济失调但无肿瘤生长,2例出现脑干受压,1例患者尽管没有肿瘤生长或症状但选择进行手术。
短期内很少有小肿瘤患者会接受手术。也许大多数此类小肿瘤患者不需要手术。需要进行20年或更长时间的长期随访研究,以便对这些肿瘤的自然病程有更确定的了解。本研究仍在继续。