Wirth A, Gohlke H
Teutoburger-Wald-Klinik, Teutoburger-Wald-Strasse 33, 49214 Bad Rothenfelde, Germany.
Z Kardiol. 2005;94 Suppl 3:III/22-9. doi: 10.1007/s00392-005-1305-z.
The prevalence of obesity has increased considerably in recent years; only one third of our population displays a desirable, healthy weight. Persons with increased body fat mass are in a constant pro-inflammatory and pro-thrombotic condition; in addition they are often insulin-resistant und show cardiovascular risk factors. Therefore, obesity induces the development of atherosclerosis as an independent risk factor as well as a promoter for other risk factors. In addition, congestive heart failure is more frequent in obese subjects. By reducing body weight with a decrease of predominantly visceral fat all risk factors are improved as well as endothelial function. Effects on coronary atherosclerosis and congestive heart disease are until now insufficiently investigated.
近年来，肥胖症的患病率显著上升；我们的人口中只有三分之一的人拥有理想的健康体重。身体脂肪量增加的人处于持续的促炎和促血栓形成状态；此外，他们往往存在胰岛素抵抗，并表现出心血管危险因素。因此，肥胖作为一个独立的危险因素以及其他危险因素的促进因素，会诱发动脉粥样硬化的发展。此外，肥胖患者发生充血性心力衰竭的情况更为常见。通过减轻体重，主要是减少内脏脂肪，可以改善所有危险因素以及内皮功能。到目前为止，对冠状动脉粥样硬化和充血性心脏病的影响研究还不够充分。
