Salomatin V V, Liutov A G, Kholodov A Iu, Sobolevskaia T M, Lifshits R I
Patol Fiziol Eksp Ter. 1992 Jan-Feb(1):35-7.
Experiments were conducted on albino noninbred mice and rats to study the effect of alpha 1-acid glycoprotein (alpha 1-AG) on burn healing. Injection of alpha 1-AG in the first 24 hours after the burn causes rapid epithelialization and increases contracture of the burn wounds. At the same time it increases the deformity of the red cells, reduces their hemolysis due to a mechanical effect, and reduces spontaneous aggregation of blood platelets. No authentic effect of alpha 1-AG on the aggregation of red cells was revealed. It is suggested that alpha 1-AG is a natural defence factor of the organism which prevents the development of microvascular thrombosis and limits in this way the size of the inflammatory and necrotic processes.
对白化非近交系小鼠和大鼠进行了实验，以研究α1-酸性糖蛋白（α1-AG）对烧伤愈合的影响。在烧伤后的头24小时内注射α1-AG可导致快速上皮化，并增加烧伤创面的挛缩。同时，它会增加红细胞的畸形，由于机械作用减少其溶血，并减少血小板的自发聚集。未发现α1-AG对红细胞聚集有确实影响。有人提出，α1-AG是机体的一种天然防御因子，可防止微血管血栓形成，并以此限制炎症和坏死过程的范围。
