Csutora Péter, Karsai Arpád, Nagy Tamás, Vas Bálint, L Kovács Gábor, Rideg Orsolya, Bogner Péter, Miseta Attila
Department of Laboratory Medicine, Pécs University, Pécs, Hungary.
Int J Neuropsychopharmacol. 2006 Oct;9(5):613-9. doi: 10.1017/S146114570500622X. Epub 2005 Nov 1.
Phosphoglucomutase catalyses the reversible conversion of glucose-6-P and glucose-1-P. Lithium is a potent inhibitor of phosphoglucomutase in vitro, however, it is not known if phosphoglucomutase was significantly inhibited by Li+ in Li+-treated bipolar patients. Here, we demonstrate that phosphoglucomutase inhibition by chronic Li+ treatment causes alterations of glucose-phosphate levels in various tissues of rats. Also, phosphoglucomutase inhibition results in compensatory elevation of phosphoglucomutase activity in rat tissues and in leukocytes isolated from Li+-treated bipolar patients. The increase of uninhibited phosphoglucomutase activity in leukocytes of Li+-treated bipolar patients is due to the increased expression of the PGM1 gene.
磷酸葡萄糖变位酶催化葡萄糖-6-磷酸和葡萄糖-1-磷酸的可逆转化。锂在体外是磷酸葡萄糖变位酶的有效抑制剂，然而，尚不清楚在接受锂治疗的双相情感障碍患者中，磷酸葡萄糖变位酶是否受到Li⁺的显著抑制。在此，我们证明，慢性锂治疗对磷酸葡萄糖变位酶的抑制会导致大鼠各种组织中磷酸葡萄糖水平的改变。此外，磷酸葡萄糖变位酶的抑制会导致大鼠组织以及从接受锂治疗的双相情感障碍患者分离出的白细胞中磷酸葡萄糖变位酶活性的代偿性升高。接受锂治疗的双相情感障碍患者白细胞中未受抑制的磷酸葡萄糖变位酶活性增加是由于PGM1基因表达增加所致。
