Cannon T D, Raine A, Herman T M, Mednick S A, Schulsinger F, Moore M
Department of Psychology, University of Pennsylvania, Philadelphia 19104.
Psychophysiology. 1992 May;29(3):294-301. doi: 10.1111/j.1469-8986.1992.tb01701.x.
Heart rate activity and computed tomographic measures of structural brain abnormalities were evaluated in 32 individuals with a genetic risk for schizophrenia (offspring of schizophrenic mothers). Heart rate activity was assessed in 1962 when the subjects were a mean age of 15.1 years. Diagnostic and computed tomography assessments were conducted in 1980. Compared to individuals with normal third ventricles, individuals with enlarged third ventricles evidenced significantly lower heart rate levels overall and significantly lower heart rate during rest and during the periods preceding conditioning and test for conditioning stimulus trials. These effects were independent of age, psychiatric diagnosis, and abnormalities in other brain regions. Difficulties in interpretation posed by the index of brain abnormality employed and by the 18-year time interval between the heart rate and computed tomography assessments are discussed. Together with prior evidence of a relationship between third ventricle enlargement and reduced electrodermal responsiveness in the same subjects, these findings provide a preliminary indication that enlargement of the third ventricle may involve damage to diencephalic structures involved in autonomic nervous system activity.
对32名有精神分裂症遗传风险的个体（精神分裂症母亲的后代）进行了心率活动和大脑结构异常的计算机断层扫描测量。1962年，当受试者平均年龄为15.1岁时评估了心率活动。1980年进行了诊断和计算机断层扫描评估。与第三脑室正常的个体相比，第三脑室扩大的个体总体心率水平显著较低，在休息期间以及条件反射训练前和条件刺激试验测试期间的心率也显著较低。这些影响与年龄、精神科诊断以及其他脑区的异常无关。讨论了所采用的脑异常指标以及心率和计算机断层扫描评估之间18年的时间间隔所带来的解释困难。连同先前关于同一受试者第三脑室扩大与皮肤电反应性降低之间关系的证据，这些发现初步表明，第三脑室扩大可能涉及参与自主神经系统活动的间脑结构受损。
