Verity C M, Winstone A M, Stellitano L, Nicoll A, Will R G
Addenbrooke's Hospital, Cambridge, UK.
Arch Dis Child. 2006 Jul;91(7):608-9. doi: 10.1136/adc.2004.071266. Epub 2005 Oct 31.
Between May 1997 and November 2004 this national prospective surveillance study identified 1007 children with "progressive intellectual and neurological deterioration" (PIND). In most cases specific diagnoses were made, but of 92 undiagnosed children with PIND 46 had died and only four underwent full necropsy. There was no clinical evidence of variant Creutzfeldt-Jakob disease (vCJD) in these undiagnosed cases, but without necropsy it is not possible to exclude vCJD completely.
在1997年5月至2004年11月期间，这项全国性前瞻性监测研究确认了1007名患有“进行性智力和神经功能衰退”（PIND）的儿童。在大多数情况下都做出了明确诊断，但在92名未确诊的PIND儿童中，46名已经死亡，只有4名接受了完整的尸检。在这些未确诊的病例中没有变异型克雅氏病（vCJD）的临床证据，但没有尸检就无法完全排除vCJD。
