中枢/外周化学感受的相互依存模型：对通气控制的证据和意义。
An interdependent model of central/peripheral chemoreception: evidence and implications for ventilatory control.
机构信息
The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
出版信息
Respir Physiol Neurobiol. 2010 Oct 31;173(3):288-97. doi: 10.1016/j.resp.2010.02.015. Epub 2010 Mar 4.
Abstract
In this review we discuss the implications for ventilatory control of newer evidence suggesting that central and peripheral chemoreceptors are not functionally separate but rather that they are dependent upon one another such that the sensitivity of the medullary chemoreceptors is critically determined by input from the carotid body chemoreceptors and vice versa i.e., they are interdependent. We examine potential interactions of the interdependent central and carotid body (CB) chemoreceptors with other ventilatory-related inputs such as central hypoxia, lung stretch, and exercise. The limitations of current approaches addressing this question are discussed and future studies are suggested.
摘要
在这篇综述中，我们讨论了新的证据对通气控制的影响，这些证据表明中枢和外周化学感受器并非在功能上彼此独立，而是相互依存的，即髓质化学感受器的敏感性取决于颈动脉体化学感受器的输入，反之亦然，即它们是相互依赖的。我们检查了相互依赖的中枢和颈动脉体（CB）化学感受器与其他与通气相关的输入（如中枢缺氧、肺扩张和运动）之间的潜在相互作用。讨论了当前解决这一问题的方法的局限性，并提出了未来的研究建议。
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