de Leval Marc R
Great Ormond Street Hospital for Children NHS Trust, London, UK.
Nat Clin Pract Cardiovasc Med. 2005 Apr;2(4):202-8. doi: 10.1038/ncpcardio0157.
The Fontan operation, which places the systemic and pulmonary circulations in series and is driven by a single ventricular chamber, is the treatment of choice for patients born with one ventricle. Its introduction 35 years ago was the result of a flurry of experimental and clinical research that had started in the 1940s. A large number of children have benefited and continue to benefit from the Fontan operation, but there is a genuine concern that, despite the refinement of the surgical procedures in the past 20 years, continuing attrition might be inevitable. This adverse effect can lead to a decline in functional capacity, and premature late death.
Fontan手术将体循环和肺循环串联起来，由单个心室驱动，是单心室出生患者的首选治疗方法。35年前它的问世是始于20世纪40年代的一系列实验和临床研究的成果。大量儿童已经并将继续从Fontan手术中受益，但人们确实担心，尽管在过去20年里手术程序有所改进，但持续的损耗可能不可避免。这种不良影响会导致功能能力下降和过早的晚期死亡。
