接受口腔和喉癌治疗的患者发生的上消化道第二原发性恶性肿瘤。
Second primary malignancy of the aerodigestive tract in patients treated for cancer of the oral cavity and larynx.
作者信息
Lin Karen, Patel Snehal G, Chu Pen Yuan, Matsuo Jeannette M S, Singh Bhuvanesh, Wong Richard J, Kraus Dennis H, Shaha Ashok R, Shah Jatin P, Boyle Jay O
机构信息
Head and Neck Service, Department of Surgery, P. O. Box 285, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10021, USA.
出版信息
Head Neck. 2005 Dec;27(12):1042-8. doi: 10.1002/hed.20272.
BACKGROUND
We aimed to identify patterns and predictors of second primary malignancy (SPM) of the aerodigestive tract (SPMADT) in patients with squamous cell carcinoma of the oral cavity (SCCOC) and larynx (SCCL).
METHODS
One thousand two hundred fifty-seven patients from two existing databases were studied: 595 with SCCOC (1986-1995) and 662 with SCCL (1984-1998). The primary endpoint of interest was development of SPMADT, defined as a second primary neoplasm of the head and neck, esophagus, or lung.
RESULTS
The 5-year SPMADT rate was 8% in the SCCL versus 10% in the SCCOC subgroup. Lung SPM was more common in the SCCL group; head and neck SPM was more common in the SCCOC group. Smokers had a fivefold increased risk, whereas alcohol use was associated with a twofold increased risk of SPMADT.
CONCLUSIONS
The rates of SPMADT after treatment of SCCOC and SCCL are comparable, but the patterns are different. Smoking and alcohol use are independent predictors of SPMADT development.
背景
我们旨在确定口腔鳞状细胞癌（SCCOC）和喉癌（SCCL）患者发生上消化道和呼吸道第二原发性恶性肿瘤（SPMADT）的模式及预测因素。
方法
对来自两个现有数据库的1257例患者进行研究：595例SCCOC患者（1986 - 1995年）和662例SCCL患者（1984 - 1998年）。感兴趣的主要终点是SPMADT的发生，定义为头颈部、食管或肺部的第二原发性肿瘤。
结果
SCCL组的5年SPMADT发生率为8%，而SCCOC亚组为10%。肺部SPM在SCCL组更常见；头颈部SPM在SCCOC组更常见。吸烟者发生SPMADT的风险增加5倍，而饮酒者的风险增加2倍。
结论
SCCOC和SCCL治疗后的SPMADT发生率相当，但模式不同。吸烟和饮酒是SPMADT发生的独立预测因素。
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