Harden R Norman, Houle Tim T, Remble Thomas A, Lin Wendy, Wang Kenten, Saltz Samuel
Center for Pain Studies, Rehabilitation Institute of Chicago/Northwestern University Medical School, Chicago, Illinois 60611, USA.
Pain Med. 2005 Sep-Oct;6(5):375-8. doi: 10.1111/j.1526-4637.2005.00060.x.
There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.
托吡酯治疗神经性疼痛的疗效证据越来越多。本文报告了对四名患有幻肢痛的截肢患者反应的详细分析。个体时间序列分析显示，四名接受托吡酯治疗的截肢参与者中有三名疼痛有统计学意义的显著减轻，每日800毫克时达到最大效果。该分析支持托吡酯可能有效减轻幻肢痛的假设，并表明有必要进行确定性研究。
