Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi Bonino-Pulejo, Messina, Italy.
J Sex Med. 2012 Dec;9(12):3274-8. doi: 10.1111/j.1743-6109.2010.01855.x. Epub 2010 May 26.
Painful ejaculation (PE) is an uncommon condition and it is usually associated with prostatitis, chronic pelvic pain syndrome, benign prostatic hyperplasia, ejaculatory duct obstruction, radical prostatectomy, and prostate radiation. Topiramate (TPM) is a new antiepileptic drug with recognized efficacy in neuropathic pain.
The study is aimed to evaluate TPM efficacy in ejaculation pain.
Following a spinal cord injury, a 53-year-old man was referred to our institute for persistent PE. Neurological examination showed mild hypoesthesia of the genital area. Urogenital examination, neurophysiological tools, and computed tomography of the dorso-lumbar spine were normal.
The main outcome measure was the visual analogue scale.
Since pain was refractory to conventional neuropathic pharmacological therapies, TPM was introduced up to 150 mg daily with a dramatic improvement of PE.
TPM may be considered as a valid therapeutic option for the treatment of PE.
射精疼痛（PE）是一种不常见的病症，通常与前列腺炎、慢性盆腔疼痛综合征、良性前列腺增生、射精管梗阻、前列腺根治术和前列腺放射治疗有关。托吡酯（TPM）是一种新型抗癫痫药物，对神经病理性疼痛有公认的疗效。
本研究旨在评估 TPM 治疗射精疼痛的疗效。
一名 53 岁男子因持续性 PE 被转介至我院。神经检查显示生殖器区域轻度感觉减退。泌尿生殖检查、神经生理工具和背腰椎计算机断层扫描均正常。
主要观察指标是视觉模拟评分。
由于疼痛对常规神经病理性药物治疗无反应，因此使用 TPM 治疗，剂量为每天 150mg，PE 得到显著改善。
TPM 可被视为治疗 PE 的有效治疗选择。
