Rossetti Z L, Melis F, Carboni S, Diana M, Gessa G L
B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Alcohol Clin Exp Res. 1992 Jun;16(3):529-32. doi: 10.1111/j.1530-0277.1992.tb01411.x.
Withdrawal of rats from chronic ethanol (2-5 g/kg, every 6 hr for 6 days) resulted in withdrawal symptomatology and dramatic fall in extracellular dopamine (DA) in the ventral striatum as measured by microdialysis. The changes in DA output paralleled the withdrawal symptomatology and both phenomena were reversed by a challenge ethanol dose (5 g/kg orally). The results suggest that the decrease in DA output may be responsible for the aversive symptoms of withdrawal.
让大鼠从慢性乙醇（2 - 5克/千克，每6小时一次，持续6天）中撤药，会导致戒断症状，并且通过微透析测量发现腹侧纹状体细胞外多巴胺（DA）显著下降。多巴胺输出的变化与戒断症状平行，且这两种现象都可被一次乙醇激发剂量（口服5克/千克）逆转。结果表明，多巴胺输出的减少可能是戒断厌恶症状的原因。
