色氨酸分解代谢：一种新降解途径的鉴定与表征
Tryptophan catabolism: identification and characterization of a new degradative pathway.
作者信息
Colabroy Keri L, Begley Tadhg P
机构信息
Department of Chemistry, Muhlenberg College, Allentown, PA 18104, USA.
出版信息
J Bacteriol. 2005 Nov;187(22):7866-9. doi: 10.1128/JB.187.22.7866-7869.2005.
Abstract
A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the intermediates 2-aminomuconate and 4-oxalocrotonate. This pathway differs from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A.
摘要
一种新的色氨酸分解代谢途径是从洋葱伯克霍尔德菌J2315中鉴定出来的。在这条途径中，色氨酸被转化为2-氨基-3-羧基粘康酸半醛，其通过中间体2-氨基粘康酸和4-草酰巴豆酸被酶促降解为丙酮酸和乙酸盐。这条途径不同于所提出的哺乳动物途径，后者将2-氨基粘康酸转化为2-酮己二酸，并最终转化为戊二酰辅酶A。
相似文献
1
Tryptophan catabolism: identification and characterization of a new degradative pathway.
J Bacteriol. 2005 Nov;187(22):7866-9. doi: 10.1128/JB.187.22.7866-7869.2005.
2
Genes for 2,4,5-trichlorophenoxyacetic acid metabolism in Burkholderia cepacia AC1100: characterization of the tftC and tftD genes and locations of the tft operons on multiple replicons.
Appl Environ Microbiol. 1998 Jun;64(6):2086-93. doi: 10.1128/AEM.64.6.2086-2093.1998.
3
Kinetic property and phylogenic relationship of 2-hydroxymuconic semialdehyde dehydrogenase encoded in tomC gene of Burkholderia cepacia G4.
Arch Pharm Res. 2004 May;27(5):570-5. doi: 10.1007/BF02980133.
4
Activity and stability of a recombinant plasmid-borne TCE degradative pathway in suspended cultures.
Biotechnol Bioeng. 1998 Feb 5;57(3):287-96.
5
Origins of the 2,4-dinitrotoluene pathway.
J Bacteriol. 2002 Aug;184(15):4219-32. doi: 10.1128/JB.184.15.4219-4232.2002.
6
Biodegradation of 2,4,5-trichlorophenoxyacetic acid by Burkholderia cepacia strain AC1100: evolutionary insight.
Gene. 1996 Nov 7;179(1):1-8. doi: 10.1016/s0378-1119(96)00326-5.
7
Degradation of 4-nitrocatechol by Burkholderia cepacia: a plasmid-encoded novel pathway.
J Appl Microbiol. 2000 May;88(5):764-72. doi: 10.1046/j.1365-2672.2000.01018.x.
8
Suppression-subtractive hybridisation reveals variations in gene distribution amongst the Burkholderia cepacia complex, including the presence in some strains of a genomic island containing putative polysaccharide production genes.
Arch Microbiol. 2003 Mar;179(3):214-23. doi: 10.1007/s00203-003-0518-7. Epub 2003 Feb 8.
9
Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharide.
Biochem Biophys Res Commun. 2003 Dec 12;312(2):323-33. doi: 10.1016/j.bbrc.2003.10.118.
10
Burkholderia genome analysis reveals new enzymes belonging to the nitrilase superfamily. The amidase of Burkholderia cepacia (hospital isolate).
Int J Biol Macromol. 2003 Dec;33(4-5):175-82. doi: 10.1016/j.ijbiomac.2003.08.002.
引用本文的文献
1
Probing the Mechanism of l‑DOPA 2,3-Dioxygenase Using Synthetic Derivatives of 3,4-Dihydroxyhydrocinnamic Acid.
ACS Omega. 2025 Jul 16;10(29):32053-32069. doi: 10.1021/acsomega.5c03691. eCollection 2025 Jul 29.
2
Recombinant Protein Spectral Library (rPSL) DIA-MS method improves identification and quantification of low-abundance cancer-associated and kynurenine pathway proteins.
Commun Chem. 2025 May 10;8(1):141. doi: 10.1038/s42004-025-01531-0.
3
Endophytic microbial communities and functional shifts in Hemarthria compressa grass in response to Silicon and Selenium amendment.
BMC Plant Biol. 2025 Feb 10;25(1):169. doi: 10.1186/s12870-025-06178-6.
4
The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review.
Metabolites. 2023 Dec 31;14(1):28. doi: 10.3390/metabo14010028.
5
Intestinal tryptophan metabolism in disease prevention and swine production.
Anim Nutr. 2023 Aug 19;15:364-374. doi: 10.1016/j.aninu.2023.08.002. eCollection 2023 Dec.
6
A Sedentary Lifestyle Changes the Composition and Predicted Functions of the Gut Bacterial and Fungal Microbiota of Subjects from the Same Company.
Curr Microbiol. 2023 Oct 13;80(12):368. doi: 10.1007/s00284-023-03480-0.
7
Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment.
Int J Biol Sci. 2023 Jun 4;19(10):2974-2998. doi: 10.7150/ijbs.85259. eCollection 2023.
8
Kynurenine Pathway Regulation at Its Critical Junctions with Fluctuation of Tryptophan.
Metabolites. 2023 Mar 30;13(4):500. doi: 10.3390/metabo13040500.
9
Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials.
Br J Cancer. 2023 Aug;129(2):185-203. doi: 10.1038/s41416-023-02245-7. Epub 2023 Apr 11.
10
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis.
Cells. 2022 Jul 25;11(15):2296. doi: 10.3390/cells11152296.
本文引用的文献
1
The pyridine ring of NAD is formed by a nonenzymatic pericyclic reaction.
J Am Chem Soc. 2005 Jan 26;127(3):840-1. doi: 10.1021/ja0446395.
2
The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.
Mol Microbiol. 2004 Apr;52(2):371-84. doi: 10.1111/j.1365-2958.2004.03999.x.
3
The bacterial oxidation of tryptophan. I. A general survey of the pathways.
J Bacteriol. 1951 Oct;62(4):355-66. doi: 10.1128/jb.62.4.355-366.1951.
4
NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
Chem Biol. 2003 Dec;10(12):1195-204. doi: 10.1016/j.chembiol.2003.11.011.
5
6
THE SYNTHESIS AND METABOLISM OF DL-TRYPTOPHAN-5-14C.
J Biol Chem. 1964 Jul;239:2184-8.
7
New intermediates in the catabolism of tryptophan in mammalian liver.
J Biol Chem. 1962 Jun;237:2043-5.
8
Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
Appl Environ Microbiol. 2003 Mar;69(3):1564-72. doi: 10.1128/AEM.69.3.1564-1572.2003.
9
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.
Biochemistry. 2002 Oct 22;41(42):12569-74. doi: 10.1021/bi026561f.
10
Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis".
J Biol Chem. 2002 Sep 20;277(38):35162-7. doi: 10.1074/jbc.M200819200. Epub 2002 Jul 24.
Zotero 插件