Koenig W, Ditschuneit H H, Hehr R, Grunewald R W, Ernst E, Hombach V
Department of Internal Medicine, University of Ulm, Germany.
Angiology. 1992 Jul;43(7):606-9. doi: 10.1177/000331979204300710.
The authors describe a thirty-eight-year-old woman with familial hypercholesterolemia treated by dextran sulfate cellulose adsorption apheresis. This technique and the selective extracorporeal LDL cholesterol elimination by immunoabsorption or heparin-induced precipitation not only dramatically decrease blood lipids but also result in a marked improvement in the rheologic profile. It is suggested that the amelioration of blood rheology by LDL apheresis may represent the cause for the early clinical improvement felt by most patients with severe coronary heart disease and hypercholesterolemia.
作者描述了一名38岁患有家族性高胆固醇血症的女性，其接受了硫酸葡聚糖纤维素吸附单采血浆术治疗。这项技术以及通过免疫吸附或肝素诱导沉淀进行的选择性体外低密度脂蛋白胆固醇清除，不仅能显著降低血脂，还能使血液流变学指标得到明显改善。有人提出，通过低密度脂蛋白单采血浆术改善血液流变学可能是大多数重症冠心病和高胆固醇血症患者早期临床症状改善的原因。
