Grützmacher P, Landgraf H, Esser R, Okon J, Vlachojannis J, Ehrly A M, Schoeppe W
St. Markus Hospital, University Hospital, Frankfurt, FRG.
ASAIO Trans. 1990 Jul-Sep;36(3):M327-30.
The effects of two different LDL apheresis techniques, heparin-induced LDL precipitation (HELP) and dextran sulfate LDL adsorption (DSA), were compared in six patients with familial hypercholesterolemia. Total and LDL cholesterol were effectively lowered with both techniques. The reduction of serum triglycerides was more pronounced with DSA, whereas the reduction of HDL cholesterol was more pronounced with HELP. Single sessions using both techniques immediately reduced whole blood and plasma viscosity, as well as erythrocyte aggregation. Serum fibrinogen decreased by 62% (HELP) and 11% (DSA). Maintenance lipid apheresis administered 1 time per week resulted in a sustained reduction of total and LDL cholesterol and was associated with a sustained improvement in blood flow properties. Data suggest that besides serum fibrinogen, serum lipoproteins may adversely effect the rheologic characteristics of blood.
对6例家族性高胆固醇血症患者比较了两种不同的低密度脂蛋白（LDL）去除技术，即肝素诱导的LDL沉淀法（HELP）和硫酸葡聚糖LDL吸附法（DSA）的效果。两种技术均能有效降低总胆固醇和LDL胆固醇。DSA使血清甘油三酯的降低更为明显，而HELP使高密度脂蛋白胆固醇的降低更为明显。两种技术单次治疗均能立即降低全血和血浆黏度以及红细胞聚集性。血清纤维蛋白原分别降低了62%（HELP）和11%（DSA）。每周进行1次维持性血脂去除治疗可使总胆固醇和LDL胆固醇持续降低，并使血流特性持续改善。数据表明，除血清纤维蛋白原外，血清脂蛋白可能对血液的流变学特性产生不利影响。
