Nakamura A, DeMaria T F, van Blitterswijk C, Lim D J
Department of Otolaryngology, Ohio State University College of Medicine, Columbus.
Ann Otol Rhinol Laryngol. 1992 Jul;101(7):607-11. doi: 10.1177/000348949210100712.
The effect of endotoxin on the growth and morphology of cultured chinchilla middle ear epithelium was examined. Within 24 hours of culture, cells maintained in medium containing endotoxin exhibited dose-dependent morphological changes. The highest concentration of endotoxin (100 mg) resulted in cell death. The growth curve of the cells in culture demonstrated a dose-dependent, significant increase in cell number when endotoxin was added to the medium.
研究了内毒素对培养的灰鼠中耳上皮细胞生长和形态的影响。在培养24小时内，培养于含内毒素培养基中的细胞呈现出剂量依赖性的形态变化。最高浓度的内毒素（100毫克）导致细胞死亡。当向培养基中添加内毒素时，培养细胞的生长曲线显示细胞数量呈剂量依赖性显著增加。
