Detjen P F, Patterson R, Noskin G A, Phair J P, Loyd S O
Division of Allergy-Immunology, Northwestern University Medical School, Chicago, Ill. 60611.
Arch Intern Med. 1992 Jul;152(7):1513-6.
We describe a 36-year-old man with recurrent Stevens-Johnson syndrome, which became progressively more severe over a 13-year period. His episodes were apparently preceded by herpes simplex virus oral mucosal infections. A management protocol, including immediate therapy with acyclovir and prednisone at the onset of herpes simplex virus oropharyngitis, is outlined. This management strategy has successfully prevented four subsequent episodes of progression to Stevens-Johnson syndrome. Thus, Stevens-Johnson syndrome associated with herpes simplex virus may be prevented by early use of acyclovir and prednisone.
