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与史蒂文斯-约翰逊综合征发病相关的高水平人疱疹病毒6型病毒血症：两例报告

High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases.

作者信息

Peppercorn Amanda F, Miller Melissa B, Fitzgerald David, Weber David J, Groben Pamela A, Cairns Bruce A

机构信息

Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, USA.

出版信息

J Burn Care Res. 2010 Mar-Apr;31(2):365-8. doi: 10.1097/BCR.0b013e3181d0f48b.

DOI:10.1097/BCR.0b013e3181d0f48b
PMID:20182379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4396637/
Abstract

The pathogenesis of Stevens-Johnson syndrome (SJS) remains obscure, but it has been associated with various infectious agents, including members of the herpesvirus family. We present the first report of high-level human herpesvirus-6 viremia at the onset of SJS, suggesting a possible new association. This finding supports the need for further investigation into the possible relationship between human herpesvirus-6 and SJS, which may illuminate the pathogenesis of SJS and bring us closer to achieving enhanced prevention and treatment of this rare disease.

摘要

史蒂文斯-约翰逊综合征（SJS）的发病机制仍不清楚，但它与多种感染因子有关，包括疱疹病毒科的成员。我们首次报告了SJS发病时出现的高水平人疱疹病毒6型病毒血症，提示可能存在一种新的关联。这一发现支持进一步研究人疱疹病毒6型与SJS之间可能的关系，这可能会阐明SJS的发病机制，并使我们更接近实现对这种罕见疾病的强化预防和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e877/4396637/cc36f98c9970/nihms677341f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e877/4396637/cc36f98c9970/nihms677341f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e877/4396637/cc36f98c9970/nihms677341f1.jpg

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2
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JAMA. 2008 Jul 23;300(4):413-22. doi: 10.1001/jama.300.4.413.
3
Herpesviruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients.多发性硬化症患者脑脊液中的疱疹病毒和人类内源性逆转录病毒序列
Mult Scler. 2008 Jun;14(5):595-601. doi: 10.1177/1352458507086425.
4
Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction.通过定量实时聚合酶链反应检测健康献血者中疱疹病毒的流行率和病毒载量。
Transfusion. 2008 Jun;48(6):1180-7. doi: 10.1111/j.1537-2995.2008.01685.x. Epub 2008 Apr 15.
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Haematologica. 2007 Oct;92(10):e98-e100. doi: 10.3324/haematol.11592.
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