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Primary antituberculosis drug resistance at Turkish military chest diseases hospital in Istanbul.伊斯坦布尔土耳其军事胸科医院的原发性耐多药结核病情况。
Med Princ Pract. 2002 Oct-Dec;11(4):202-5. doi: 10.1159/000065815.
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Prospects for development of new antimycobacterial drugs.新型抗分枝杆菌药物的研发前景。
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In vitro activity of four fluoroquinolones against Mycobacterium tuberculosis.四种氟喹诺酮类药物对结核分枝杆菌的体外活性。
Int J Antimicrob Agents. 2001 Mar;17(3):229-31. doi: 10.1016/s0924-8579(00)00337-x.
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Comparative antimycobacterial activities of ofloxacin, ciprofloxacin and grepafloxacin.氧氟沙星、环丙沙星和格帕沙星的抗分枝杆菌活性比较。
J Antimicrob Chemother. 1999 Nov;44(5):647-52. doi: 10.1093/jac/44.5.647.
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Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998. Joint Tuberculosis Committee of the British Thoracic Society.英国结核病的化疗与管理：1998年建议。英国胸科学会联合结核病委员会
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In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages.十四种抗菌药物对药物敏感和耐药的结核分枝杆菌临床分离株的体外活性以及对人巨噬细胞中强毒株H37Rv的细胞内活性比较
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环丙沙星、氧氟沙星和左氧氟沙星对结核分枝杆菌的体外活性。

In vitro activity of ciprofloxacin, ofloxacin and levofloxacin against Mycobacterium tuberculosis.

作者信息

Akcali Sinem, Surucuoglu Suheyla, Cicek Candan, Ozbakkaloglu Beril

机构信息

From Celal Bayar University, Izmir, Turkey.

出版信息

Ann Saudi Med. 2005 Sep-Oct;25(5):409-12. doi: 10.5144/0256-4947.2005.409.

DOI:10.5144/0256-4947.2005.409
PMID:16270765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6089726/
Abstract

BACKGROUND

The increasing incidence of drug-resistant Mycobacterium tuberculosis necessitates therapeutic alternatives. The fluoroquinolones fulfill most of the criteria for an ideal class of antimycobacterial drugs. The aim of the present study was to determine to in vitro activities of ciprofloxacin, ofloxacin, and levofloxacin against M. tuberculosis strains.

METHODS

Susceptibility to four antituberculous drugs used in first-line treatment of tuberculosis was tested in 100 strains isolated from clinical samples. Nineteen strains (19%) were resistant to at least one of the four antituberculous drugs and 13 were multidrug resistant. The in vitro antimycobacterial activity of ciprofloxacin, ofloxacin, and levofloxacin was then determined against 100 M. tuberculosis strains using standard agar proportion dilution method.

RESULTS

Ciprofloxacin, ofloxacin, and levofloxacin were active against all tested strains of M. tuberculosis in vitro.

CONCLUSIONS

Ciprofloxacin, ofloxacin, and levofloxacin have relatively potent in vitro activity against M. tuberculosis. Further in vivo studies are needed to determine the role of these compounds in the treatment of tuberculosis, but use should be limited to special circumstances rather than first-line treatment.

摘要

背景

耐多药结核分枝杆菌发病率的上升使得有必要寻找替代治疗方法。氟喹诺酮类药物符合理想抗分枝杆菌药物类别的大部分标准。本研究的目的是确定环丙沙星、氧氟沙星和左氧氟沙星对结核分枝杆菌菌株的体外活性。

方法

对从临床样本中分离出的100株菌株进行了用于结核病一线治疗的四种抗结核药物的敏感性测试。19株（19%）对四种抗结核药物中的至少一种耐药，13株为多重耐药。然后使用标准琼脂比例稀释法测定环丙沙星、氧氟沙星和左氧氟沙星对100株结核分枝杆菌菌株的体外抗分枝杆菌活性。

结果

环丙沙星、氧氟沙星和左氧氟沙星在体外对所有测试的结核分枝杆菌菌株均有活性。

结论

环丙沙星、氧氟沙星和左氧氟沙星对结核分枝杆菌具有相对较强的体外活性。需要进一步进行体内研究以确定这些化合物在结核病治疗中的作用，但使用应限于特殊情况而非一线治疗。