Baldelli Alberto, Liang Mingtao
Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, Canada.
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
Front Drug Deliv. 2023 Jun 14;3:1209534. doi: 10.3389/fddev.2023.1209534. eCollection 2023.
Antibiotic resistance is exponentially increasing, and the number of deaths caused by bacterial infections is expected to surge. When dealing with the respiratory system, inefficient antibiotics heighten the chance of death from bacterial infection. However, the alternatives to antibiotics are limited. Bacteriophages are a valid option since they can target a specific type of bacterium. Bacteriophages are highly specific and can avoid any side effects when delivered. However, their poor stability makes their use inefficient. Encapsulation is commonly used to protect any bioactive compound for different types of delivery. In the case of respiratory delivery, particle engineering is used to generate stable dry powders to target the nasal or lung areas. This review article provides a guideline for engineering a process of nasal dry powders of encapsulated bacteriophages.
抗生素耐药性正在呈指数级增长，预计由细菌感染导致的死亡人数将会激增。在应对呼吸系统问题时，低效的抗生素会增加因细菌感染而死亡的几率。然而，抗生素的替代物却很有限。噬菌体是一种可行的选择，因为它们能够靶向特定类型的细菌。噬菌体具有高度特异性，在递送时可以避免任何副作用。然而，它们稳定性差，导致其使用效率低下。封装通常用于保护任何生物活性化合物以实现不同类型的递送。在呼吸道递送的情况下，颗粒工程用于制备稳定的干粉以靶向鼻腔或肺部区域。这篇综述文章为封装噬菌体鼻腔干粉的工程化过程提供了指导方针。
