伏立康唑成功治疗曲霉性支气管炎和曲菌球
[Aspergillus bronchitis and aspergilloma treated successfully with voriconazole].
作者信息
Freymond N, Le Loch J-B, Devouassoux G, Harf R, Rakotomalala A, Pacheco Y
机构信息
Service de Pneumologie et d'Immunologie Clinique, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
出版信息
Rev Mal Respir. 2005 Nov;22(5 Pt 1):811-4. doi: 10.1016/s0761-8425(05)85639-6.
INTRODUCTION
Aspergillus fumigatus is a ubiquitous soil-dwelling organism, which can cause both aspergillomas which develop in a preformed lung cavity, and aspergillus bronchitis. The two pathologies can occasionally co-exist, notably in patients with of cystic fibrosis.
CASE REPORT
We describe a 57 year old patient, with diffuse bronchiectasis, who developed aspergillus bronchitis as well as an aspergilloma complicating a cavity caused by an atypical mycobacterial infection. After one month of therapy with voriconazole the aspergilloma had decreased in size and the endobronchial changes had resolved.
CONCLUSION
This case report illustrates that in addition to its established role for the treatment of invasive aspergillosis, voriconazole is a promising new therapy for the treatment of aspergilloma and aspergillus bronchitis.
引言
烟曲霉是一种广泛存在于土壤中的微生物，可导致在预先形成的肺空洞中发展的曲菌球以及曲霉性支气管炎。这两种病症偶尔会同时存在，尤其是在囊性纤维化患者中。
病例报告
我们描述了一名57岁患有弥漫性支气管扩张的患者，其发生了曲霉性支气管炎以及由非典型分枝杆菌感染引起的空洞并发曲菌球。在接受伏立康唑治疗一个月后，曲菌球体积减小，支气管内病变得到缓解。
结论
本病例报告表明，除了在治疗侵袭性曲霉病方面已确立的作用外，伏立康唑是治疗曲菌球和曲霉性支气管炎的一种有前景的新疗法。
Zotero 插件