Lim Chol Seung, Jin Da-Qing, Mok Hyejung, Oh Sang Jin, Lee Jung Uk, Hwang Jae Kwan, Ha Ilho, Han Jung-Soo
Drug Discovery Research Division, Hanwha CC R&D Center, Daejeon, South Korea.
J Neurosci Res. 2005 Dec 15;82(6):831-8. doi: 10.1002/jnr.20692.
Xanthorrhizol, a natural sesquiterpenoid isolated from the rhizome of Curcuma xanthorrhiza Roxb (Zingiberaceae), has antibacterial activities and protective effects against cisplatin-induced hepatotoxicity. In this study, we investigated the activities of xanthorrhizol as an antioxidant or antiinflammatory agent using neuronal and microglial cells. Xanthorrhizol had potent neuroprotective effects on glutamate-induced neurotoxicity and reactive oxygen species (ROS) generation in the murine hippocampal HT22 cell line. Also, xanthorrhizol inhibited H(2)O(2)-induced lipid peroxidation in rat brain homogenates. The properties of xanthorrhizol as an antiinflammatory agent were investigated in microglial activation by lipopolysaccharide. It reduced the expression of cyclooxygenase-2 and the inducible nitric oxide synthase, which consequently resulted in the reduction of nitric oxide. The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha in activated microglial cells, was reduced by xanthorrhizol. These results suggest that xanthorrhizol could be an effective candidate for the treatment of Alzheimer's disease- and other neurological disease-related ROS and inflammation.
姜黄醇，一种从郁金（姜科）根茎中分离出的天然倍半萜类化合物，具有抗菌活性以及对顺铂诱导的肝毒性的保护作用。在本研究中，我们利用神经元细胞和小胶质细胞研究了姜黄醇作为抗氧化剂或抗炎剂的活性。姜黄醇对谷氨酸诱导的小鼠海马HT22细胞系神经毒性和活性氧（ROS）生成具有强大的神经保护作用。此外，姜黄醇抑制大鼠脑匀浆中过氧化氢诱导的脂质过氧化。通过脂多糖诱导小胶质细胞活化来研究姜黄醇作为抗炎剂的特性。它降低了环氧合酶-2和诱导型一氧化氮合酶的表达，从而导致一氧化氮减少。姜黄醇减少了活化小胶质细胞中促炎细胞因子如白细胞介素-6和肿瘤坏死因子-α的产生。这些结果表明，姜黄醇可能是治疗阿尔茨海默病及其他神经疾病相关的活性氧和炎症的有效候选药物。
