Wilson D W, Turkes A, Jones R, Danutra V, Read G F, Griffiths K
Tenovus Institute for Cancer Research, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Eur J Cancer. 1992;28A(6-7):1162-7. doi: 10.1016/0959-8049(92)90478-k.
Menstrual-cycle profiles of salivary progesterone concentration, obtained by radioimmunoassay of daily samples collected throughout the cycle, were obtained from Thai (n = 232) and British (n = 130) adolescent girls up to 4 years postmenarche. These profiles were graded from 1 to 5 ranging, respectively from concentrations at the detection limit of the assay to profiles generally observed for the mature premenopausal woman. Contingency table analysis of the grade frequencies for Thai-British pairs of girls matched for chronological age and age at menarche (n = 2 x 90) demonstrated that British girls had more mature cycles (22/90) than Thais (11/90) (P less than 0.05) particularly in the first 2 years postmenarche (P less than 0.01). For these matched pairs of girls there was no evidence to support the view that girls with an early age of menarche develop their profiles more quickly following menarche than those with a late age of menarche, as previously reported and which was thought to be important in the development of breast cancer. The findings of this study also suggest that adolescent girls in Britain develop their menstrual cycle profiles of salivary progesterone more quickly than their Thai counterparts and this may be of value in formulating hypotheses regarding any role that ovarian progesterone secretion may have on subsequent breast cancer risk.
通过对泰国（n = 232）和英国（n = 130）初潮后4年内的青春期女孩整个月经周期每日采集的唾液样本进行放射免疫测定，获得了唾液孕酮浓度的月经周期曲线。这些曲线从1到5分级，分别对应于测定检测限的浓度到成熟绝经前女性通常观察到的曲线。对按实足年龄和初潮年龄匹配的泰国-英国女孩对（n = 2×90）的分级频率进行列联表分析表明，英国女孩的月经周期比泰国女孩更成熟（22/90）（P<0.05），尤其是在初潮后的头两年（P<0.01）。对于这些匹配的女孩对，没有证据支持如下观点：如初潮早的女孩初潮后比初潮晚的女孩更快形成她们的曲线，正如之前报道的那样，并且这被认为在乳腺癌的发生中很重要。本研究结果还表明，英国青春期女孩唾液孕酮的月经周期曲线比泰国同龄人形成得更快，这对于就卵巢孕酮分泌可能对后续乳腺癌风险所起的任何作用提出假设可能有价值。
