Greyson C, Weiner M W
University of California, San Francisco.
Curr Opin Radiol. 1992 Aug;4(4):48-54.
Magnetic resonance spectroscopy provides information about metabolic processes in living tissues. The resulting information may be more sensitive and specific than that obtained using techniques that rely on functional or structural measurements. Although the preponderance of applications to date have been in physiologic investigations in animals, clinical applications are emerging. Reports in the past two years have appeared evaluating the clinical use of phosphorus spectroscopy to detect ischemic heart disease, cardiomyopathy, and cardiac transplant rejection. Active research using nuclei other than phosphorus for spectroscopy will expand the potential clinical applications. Technical developments, including improved surface coil design, wider use of high-field magnets and new pulse sequences, will allow improved sensitivity and spatial localization in the future.
磁共振波谱学提供了有关活体组织代谢过程的信息。所得到的信息可能比使用依赖功能或结构测量的技术所获得的信息更敏感、更具特异性。尽管迄今为止大多数应用都用于动物的生理学研究，但临床应用正在兴起。过去两年已有报告评估了磷波谱学在检测缺血性心脏病、心肌病和心脏移植排斥反应方面的临床应用。使用除磷以外的原子核进行波谱学的积极研究将扩大潜在的临床应用。技术发展，包括改进的表面线圈设计、高场磁体的更广泛使用和新的脉冲序列，将在未来提高灵敏度和空间定位。
