Hudsmith Lucy E, Neubauer Stefan
Cardiology at Queen Elizabeth Hospital, Birmingham, UK.
Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S49-56. doi: 10.1038/ncpcardio1158.
Magnetic resonance spectroscopy (MRS) utilizes magnetic resonance signals from nuclei, such as phosphorus-31, to provide information regarding the biochemical composition and metabolic state of cardiac muscle. This technique is the only method available for noninvasive assessment of cardiac metabolism without the need for the application of external radioactive tracers. MRS provides insights into the role of cardiac energetics in ischemic heart disease, heart failure, hypertrophy, and valve disease. Furthermore, response to therapeutic intervention can be monitored using this method. At present, this technique is used as a research tool, because low spatial and temporal resolution, as well as low reproducibility, precludes its diagnostic use in clinical practice; however, higher-field magnetic resonance systems-using, for example, 7 T-will enable improvements in resolution and reproducibility that may take cardiac MRS into the clinical realm.
磁共振波谱（MRS）利用来自原子核（如磷-31）的磁共振信号，来提供有关心肌生化组成和代谢状态的信息。该技术是唯一可用于无创评估心脏代谢且无需应用外部放射性示踪剂的方法。MRS有助于深入了解心脏能量代谢在缺血性心脏病、心力衰竭、心肌肥大和瓣膜病中的作用。此外，可使用该方法监测对治疗干预的反应。目前，由于空间和时间分辨率低以及可重复性差，该技术仅用作研究工具，无法在临床实践中用于诊断；然而，更高场强的磁共振系统（例如使用7T）将提高分辨率和可重复性，从而可能使心脏MRS进入临床应用领域。
